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What Causes Autoimmunity?
One reoccurring theme you see over and over again in the scientific literature about autoimmune diseases is that they are caused by the combination of genetics and toxins.
“Genetic and epigenetic factors interacting with the environment over time are the main causes of complex diseases such as autoimmune diseases.” 1
“It's likely that lupus results from a combination of your genetics and your environment.” — The Mayo Clinic 2
“Type 1 (Diabetes) is thought to be caused by a combination of genetic susceptibility and environmental factors …” — The Mayo Clinic 3
So what are these “environmental factors” causing autoimmune diseases and where are they found?
Autoimmune Toxin #3 — GMOs
What are GMOs?
GMOs or “Genetically Modified Organisms” are plants that have had their DNA artificially modified at a genetic level. This artificial modification involves combining the DNA of plants with animal, bacteria, or viruses creating organisms that do not occur in nature or by normal crossbreeding methods. The purpose of this genetic modification is to enable the plants to withstand deadly doses of herbicides and pesticides.
Is There A Link With GMOs and Autoimmune Diseases?
Yes! They cause leaky gut, disrupt gut bacteria, and all conditions which are foundational to autoimmune diseases. Thus GMO's lay the ground work to trigger an autoimmune disease.
Glyphosate
Researches have found “clear evidence that glyphosate disrupts gut bacteria.” 4 Why is this important?
An imbalance of gut bacteria has been found in every autoimmune disease in which its presence has been investigated. 5
And this disruption in gut bacteria is also directly linked to other health conditions such as:
“gastrointestinal disorders, obesity, diabetes, heart disease, depression, autism, infertility, cancer and Alzheimer’s disease.” 6
Did you notice that many of these health issues are also very common in autoimmunity sufferers? Science brings out yet another link between glyphosate and autoimmune diseases in how it prevents protein digestion. Notice…
“glyphosate may interfere with the breakdown of complex proteins in the human stomach, leaving larger fragments of wheat in the human gut that will then trigger an autoimmune response …" 7
The body doesn't recognize the partially digested proteins and attacks them, which in turn leads to the immune system attacking other parts of the body that look chemically similar.
Here is a list of more health issues associated with glyphosate:
- Is a probable cancer-causing carcinogen 8
- Depletes tryptophan leading to insomnia and depression 9
- Turns normal food allergenic 10
- Disrupts production of bile leading to fat malabsorption 11
- Systemic inflammation due to destruction of gut lining 12
- Inhibits specific enzymes that play an important role in detoxification 13
- Causes other toxins to be even more damaging 14
- Binds to nutrients leading to mineral deficiencies 15
- Liver and kidney disease (in animal studies) 16
As you look at this list, remember that GMO foods have the highest concentration of glyphosate which is why it's so important to avoid them.
Leaky Gut
Glyphosate damages the delicate walls of the small intestine causing what’s known as “leaky gut.” The intestinal wall is lined with a protective layer that absorbs nutrients but keeps out harmful substances from getting into the blood stream.
When leaky gut occurs, it causes openings between the cells that line the gut wall. Then particles in the digestive tract, both good and bad, can enter into the bloodstream which triggers autoimmune and allergic reactions.
Leaky gut is one of the main steps in the development of autoimmune diseases and has been found every time its presence was investigated in an autoimmune disease.17
Here are frames of a video showing an actual lab experiment in which glyphosate degraded the tight junctions cells of the small intestine in just 16 minutes!
Photo Courtesy of: restore4life
Immunofluorescence coloring is making visible the cells' tight junctions and nuclei. The green highlighted sections are showing the tight junction walls between small intestine cells and the blue shows the nuclei of cells. Notice how by minute 16 the green tight junction walls are almost completely disintegrated. Scary.
GMO Corn
Another example of intestinal damage by GMOs can be found in genetically modified corn which produces its own bacteria called Bt-toxin that kills insects by exploding their stomachs after eating it. For this reason, Bt-toxin is often called the “hole-punching toxin” since it punches holes in the bugs digestive tracts.
However a 2013 study that looked at the effects of Bt insecticidal toxins on humans found that it’s also lethal to human cells. 18 Not surprising, is it? This combined with loads of clinical evidence suggest that GMO corn is probably “punching holes” in our digestive tracts also.
The second reason why GMOs are dangerous is because of the genetic modification done to GMO plants.
It had been difficult to get the companies responsible for GMO plants to perform unbiased scientific studies on their own GMO products. However, a nine-week study on rats was performed and concluded that they found no detrimental health effects. France decided to do the same study feeding GMO food to rats, but instead of limiting the study to the extremely short nine weeks, they extended it to 9 - 24 months. 19
What happened? The rats formed enormous tumors about a third the size of their bodies, they had severe liver damage, and acquired digestive problems. Several of the rats had to be euthanized because they were is so much pain from the tumors. The results of this study lead France to ask for a Europe-wide ban of GMO corn.
Rats fed GM potatoes developed: 23
- Potentially pre-cancerous cell growth in the digestive tract
- Smaller brains, livers, and testicles
- Partial atrophy of the liver
- Immune system damage
So What Do You Do?
Number one, you have to avoid these GMO foods like the plague.
Maybe you're thinking, "I avoid GMOs and I don't feel any better."
Most likely you're not.
People tell my wife and I this all the time but then we find GMOs in their cabinets everywhere.
GM foods hide in so many unknown places and they’re in thousands of products!
I’ll show you how to find and avoid these foods, and how my wife and I stay clear of them when we eat out at restaurants.
What do you do if you’ve been eating GMOs for years?
I’ll show you what to do about that too!
But on to the next toxin.
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References
1. Barragán-Martínez, Carolina et al. “Organic Solvents as Risk Factor for Autoimmune Diseases: A Systematic Review and Meta-Analysis.” Ed. Sudha Chaturvedi. PLoS ONE 7.12 (2012): e51506. PMC. Web. 27 Feb. 2018.
2. Mayo Clinic
3. Mayo Clinic
4. Anthony Samsel, Stephanie Seneff “Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases” Entropy 2013, 15(4), 1416-1463
5. Sarah Ballantyne, Ph.D. “Lifestyle and Autoimmune Disease (AHS14)” Ancestry Foundation Aug 23, 2014
6. Samsel, Seneff, Entropy 2013.
7. Samsel A, Seneff S. “Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance. Interdisciplinary” Toxicology. 2013;6(4):159-184.
8. Portier CJ, Armstrong BK, Baguley BC, et al “Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA)” J Epidemiol Community Health Published Online First: 03 March 2016.
9. Samsel , Seneff. Toxicology. 2013;
10. Dr. Karin C. Holstein, “Glyphosate the Real Culprit behind Gluten Sensitivity." 2016
11. ibid
12. ibid
13. Anthony Samsel, Stephanie Seneff “Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases” Entropy 2013, 15(4), 1416-1463
14. ibid
15. ibid
16. Kilic A, Akay MT. “A three generation study with genetically modified Bt corn in rats: Biochemical and histopathological investigation.” Food and Chemical Toxicology, 46: 1164-1170, 2008.
17. Ballantyne, “Lifestyle and Autoimmune Disease (AHS14)” Ancestry Foundation Aug 23, 2014
18. Mesnage R, Clair E, Gress S, Then C, Szekacs A, Seralini GE. "Cytotoxicity on human cells of Cry1Ab and Cry1Ac Bt insecticidal toxins alone or with a glyphosate-based herbicide." J Appl Toxicol. 2013;33 (7):695-699.
19. Séralini, G. E., et al. (2012). “Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize.” Food and Chemical Toxicology 50(11): 4221-4231.
20. David Schubert, “Regulatory regimes for transgenic crops.” letter in Nature Biotechnology 23 (2005): 785-787; citing R. Betarbet, T.B. Sherer, G. MacKenzie, et al., “Chronic systemic pesticide exposure reproduces features of Parkinson’s disease,” Nature Neuroscience 3 (200): 1301-1306.
21. UK Daily Express, 12 March 1999 p.28
22. Arpad Pusztai, Susan Bardocz and Stanley W.B. Ewen, “Genetically modified foods: potential human health effects” (CABI April 2003) 3,4.
23. Stanley WB Ewen, Arpad Pusztai, “Effect of diets containing genetically modified potatoes expressing Galanthus nivalis-lectin on rat small intestine” The Lancet Volume 354, No. 9187, p1353–1354, 16 October 1999
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